People who are very overweight have a characteristic gut microbiome. The bacterial strains Bacillota, Fusobacteriota and Pseudomonadota occur more frequently, whereas genera of the phyla Bacteroidota and Actinomycetota are reduced. In particular, many species of Gram-positive Bacillota (formerly known as Firmicutes), which are excellent carbohydrate fermenters, increase the calorie yield from food and promote the formation of fat stores. In addition, the other two groups of bacteria mentioned have germs with harmful to long-term pathogenic properties. The microbiota also intervenes directly in the human sense of hunger via the intestinal/brain axis and through the production of mimetic appetite-regulating peptides and metabolites. The increased Bacillota/Bacteroidota ratio can be rebalanced by changing the diet to include secondary plant fiber, polyphenol-rich foods (berries, herbs, fruits) and prebiotics. An exact analysis of the intestinal bacterial species that occur allows the creation of a nutritional program tailored to you and thus supports your weight loss routine.
Profile focus: Brief report intestinal microbiome (with Bacillota/Bacteroidota ratio, proportion of pathogenic Pseudomonadota), carbohydrate and fat-utilizing bacteria, species with appetite-regulating bacterial mimetic peptides and metabolites, species associated with obesity.
